I'm quite late to this, but I saw the first 3 episodes of Girls today.... all the characters are annoying as hell! The show has many virtues; I am not commenting on the greatness or quality of the show, just the fact that I'm not sure it resonates with me. It is interesting for me to wonder why I found it to be so annoying. Most shows have a few characters that can be irksome, but vexation appears to be a universal feature of the Girls universe. The characters in the show all appear to defy some professional or personal ethic that exists in my mind, and that I clearly value enough to be annoyed at its flagrant violation in a show that has clear intentions to satirize.
I don't think that my annoyance with the characters is because of any patriarchal reasons. I think I am primarily irked by the depiction of character flaws such as self-absorbed narcissism and irresponsibility. Would I have found them less annoying and more comedic in a male character? I don't think so, but I am possibly not the best judge of that.