I discovered this excellent article about following your 'personal calling' by Surmed Shakeel on his blog, and i highly recommend reading it.
Here is an extract from it:
'So why is it so important to live our personal calling if we are only going to suffer more than other people?
Because once we have overcome the defeats - and we always do - we are filled with a greater sense of euphoria and confidence. in the silence if our hearts we know that we are proving ourselves worthy of the miracle of life. each day each hour is part of the good fight. we start to live with enthusiasm and pleasure. intense, unexpected suffering passes more quickly then suffering that is apparently bearable; the latter goes on for several years and without our noticing eats away at our soul until one day we are no longer able to free ourselves from the bitterness and it stays with us for the rest of our lives.'